Polynucleotides are derived from salmon DNA fragments and work by supporting the body’s natural processes of tissue repair and regeneration, making them a safe treatment. Their safety profiles are excellent, and ongoing studies continue to show no harmful long-term effects.

Polynucleotide treatment involves injecting the product which is more “stingy” than some other injectable treatments. We use topical numbing cream to minimise your discomfort.

Since polynucleotides are a regenerative treatment that works at a cellular level by stimulating your cells to produce more collagen and elastin, the first signs of improvement often begin around 2-3 weeks after your first treatment, with the full effects visible at around 12 weeks.

An initial course of 3 treatments are required, each two to four weeks apart. A consultation with at our Sheffield clinic will help determine the number of sessions that is right for you.

A single top-up session every 9-12 months is then recommended to help sustain optimal results.

Results can last between 9 to 12 months, depending on factors such as individual metabolism, lifestyle choices, diet, hydration, sun exposure, and skincare routines. Having a maintenance treatment every 9-12 months will ensure optimal results.

When a cannula is used, you can expect a brief downtime of 12 to 24 hours. For treatments using a needle, small bumps (blebs) may appear at the injection sites, typically fading within 2 days.

1.Minimise Dark Circles - One of the primary concerns for many individuals is the presence of dark circles under the eyes. Polynucleotide treatment reduces the pigmentation and discoloration that contribute to the appearance of these dark circles. Impressively, results show that Polynucleotide Eyes improves under eye brightness in individuals by over 32 percent in as little as 4 weeks.

2.Improves Skin Elasticity - Loss of skin elasticity is a common sign of aging, leading to the formation of fine lines and wrinkles. Polynucleotide treatment promotes greater skin elasticity, restoring a more youthful and supple appearance to the under-eye area. Polynucleotides are proven to increase skin elasticity by 22 percent on average in just weeks.

3.Reduces the look of under-eye hollows - Deep tear troughs can create a tired and sunken look. While Polynucleotides do not fill out these hollows like traditional filler, the treatment does help to subtly reduce the appearance of these under-eye depressions by plumping and rejuvenating the skin in this area.

4.Increases Cell Turnover - Cell turnover is essential for maintaining healthy and vibrant skin. Polynucleotide Treatment increases cell turnover, resulting in a fresher and more rejuvenated under-eye area.

Protects Against Free Radical Damage - Free radicals are unstable molecules that can damage the skin and accelerate the aging process. Polynucleotide eyes possesses antioxidant properties that help protect the under-eye area from free radical damage, promoting overall skin health.

5.Hydrated under eyes - Hyaluronic acid is a natural substance found in the skin that helps retain moisture and maintain hydration. Polynucleotides stimulates higher hyaluronic acid synthesis, ensuring that the under-eye area remains hydrated and plump.

6.Minimises Fine Lines and Wrinkles - Fine lines and wrinkles can be a source of frustration for many individuals. Polynucleotide Treatment stimulates collagen and elastin production. The improved skin elasticity reduces the appearance of fine lines and wrinkles around the eyes, helping to promote a smoother under-eye area

Improved Skin Texture - Polynucleotides have the ability to improve skin texture, creating a smoother and more refined under-eye area. This treatment can help reduce the appearance of roughness and unevenness, resulting in a refreshed and youthful look.

This depends on how your under eye looks and what you wish to treat. If your concern is hollows only and you are not prone to puffiness (eye bags) under eyes then tear trough filler is the best option.

If you are concerned with fine lines / crepey skin under the eye and / or dark circles OR you prone to eye puffiness (eye bags) then Polynucleotides eyes is the best option.

Polynucleotides (PN) is a very thin water-like substance that improves skin quality on a cellular level whereas traditional under eye filler/Tear Trough filler is hyaluronic acid gel which is a much more viscous substance and is used to fill hollows under eyes.

Polynucleotide treatment works with the body's DNA to promote skin regeneration. This innovative treatment stimulates collagen and elastin production, which are essential proteins for maintaining the skin's structure and elasticity and works to treat fine lines and dark eye circles.

Tear trough filler can sometimes make the under-eye area appear puffier, as hyaluronic acid attracts water and can migrate. Polymononucleotide eyes will not ‘fill’ the under eye area and will not cause puffiness or migration of the product.

Below is a guide to choosing the best treatment for your specific concern:

-More natural-looking results: Polynucleotides gradually improve skin quality, avoiding potential overfilling and a "done" look.

-Better for skin health: Polynucleotides stimulate collagen and elastin production, leading to long-term improvement in skin quality.

-Fewer side effects: Polynucleotides Generally considered less risky than fillers, with minimal downtime and rare allergic reactions.

Suitable for sensitive skin: Polynucleotides may be preferable for those with thin or sensitive skin.

-Under-eye fillers might be a better option for: Significant volume loss: Fillers can effectively address very deep tear troughs and hollowness that polynucleotides wouldn't.

Immediate results: Fillers offer instant correction for those seeking a quick turnaround.

Ultimately, the best choice for you depends on your individual concerns and desired outcome. Consulting our highly qualified aesthetic doctor is crucial to understand your options and make an informed decision based on your specific needs and goals.

Both polynucleotide and Profhilo treatments are popular injectable options for skin rejuvenation, but they have key differences in their composition, mechanisms of action, and suitability for different concerns. Both Polynucleotides and Profhilo are skin boosters but are made up of different ingredients and work in different ways:

Polynucleotides are DNA extracts which is a form of “regenerative medicine” it is a water-based substance that stimulates your own body’s collagen and elastin production to create healthier, younger-looking, rejuvenated skin by working on a cellular level. It does not contain hyaluronic acid, so does not draw in water or give much plumping of the skin as profhilo does.

Profhilo is hyaluronic acid which is injected into the skin to give a hydration and plumping but it does not regenerate the skin on a cellular level in the way polynucleotide does. Profhilo is a thicker (more viscous product) which acts like a ‘honey”spreading under the skin and drawing in water so can give a more plumped appearance than Polynucleotides tend to.

Polynucleotides can be used around eyes and on forehead which Profhilo can not be. Both polynucleotides and Profhilo are suitable for use on cheeks, neck, décolletage and stomach.

Both polynucleotides and profhilo require a course of initial treatments then maintenance treatments for optimal results.

When polynucleotides are injected into the skin, they work by stimulating the body’s natural repair mechanisms, repairing damaged cells, boosting collagen and elastin production. The also possess anti-inflammatory properties, so can reduce redness and swelling, making them useful for treating conditions like acne and rosacea. Polynucleotides increase the skin’s ability to retain moisture, resulting in and a more hydrated complexion so are excellent for treating dry / dehydrated skin. They can accelerate the wound healing process, helping to minimise recovery from ablative procedures like laser treatments or microneedling and can be used to reduce the appearance of stretch marks and acne scarring.

Polynucleotide treatment is suitable for most skin types and can benefit anyone looking to improve skin elasticity, reduce fine lines, and achieve a more youthful appearance. If you are pregnant or breast-feeding or have a fish allergy this treatment is not suitable. If you are vegan this treatment is not suitable as it is an animal derived product.

A consultation with Dr Naren at our Sheffield clinic will help determine if this treatment is right for you.